hrp0084p2-294 | Diabetes | ESPE2015

The Prevalence of Different Subtypes of Maturity-Onset Diabetes of the Young in Russian Federation as Defined by Targeted Next-Generation Sequencing

Zubkova Natalya , Gioeva Olesya , Tichonovich Yulia , Petrov Vasily , Vasilyev Evgeny , Malievsky Oleg , Kiyaev Alexey , Timofeev Alexey , Tiulpakov Anatoly

Background: Among the currently known variants of maturity-onset diabetes of the young (MODY) subtypes 1–3 are the most prevalent, while their relative frequencies vary in different populations. Other types of MODY are more rare, although the studies addressing their prevalences are limited. Recent implementation of next-generation sequencing (NGS) enables simultaneos analysis of multiple candidate genes making it an attracive approach in various monogenic disorders, incl...